Electrical Conduction in Canine Pulmonary Veins

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Electrical conduction in canine pulmonary veins: electrophysiological and anatomic correlation.

BACKGROUND Paroxysmal atrial fibrillation in patients is often initiated by foci in the pulmonary veins. The mechanism of these initiating arrhythmias is unknown. The aim of this study was to determine electrophysiological characteristics of canine pulmonary veins that may predispose to initiating arrhythmias. METHODS AND RESULTS Extracellular recordings were obtained from the luminal side of...

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Electrical impulse conduction in pulmonary veins.

It has been documented that the cardiac musculature of many mammalia, including man, extends from the heart along the pulmonary veins to the lungs, and, at least in some rodentia, as far as the small venules, and that smooth muscle is not present (1-3). However, these reports are of structural studies only, and in the one publication where a speculation is made concerning the spread of the cont...

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Correlation between anatomy and electrical activation in canine pulmonary veins.

BACKGROUND The roles of complex muscle sleeve geometry and fiber orientation in the pulmonary veins (PVs) in wave-front propagation are poorly understood. METHODS AND RESULTS We mapped the left superior PV (LSPV, n=7) and left inferior PV (LIPV, n=4) of dogs with 420 bipolar electrodes (1-mm resolution) and performed detailed histological examination. In the anterior LSPV-left atrial (LA) jun...

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Arrhythmia/Electrophysiology Mechanisms by Which Adenosine Restores Conduction in Dormant Canine Pulmonary Veins

Received July 9, 2009; accepted January 4, 2010. From the Department of Medicine (T.D., L.M., X.-Y.Q., P.C., D.C., P.G., S.N.), Montreal Heart Institute Research Center and Université de Montreal; the Department of Pharmacology and Therapeutics (S.N.), McGill University, Montreal, Quebec, Canada; and the Department of Cardiology (T.D., A.A., F.F.-A.), Hospital General Universitario Gregorio Mar...

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Mechanisms by which adenosine restores conduction in dormant canine pulmonary veins.

BACKGROUND Adenosine acutely reconnects pulmonary veins (PVs) after radiofrequency application, revealing "dormant conduction" and identifying PVs at risk of reconnection, but the underlying mechanisms are unknown. METHODS AND RESULTS Canine PV and left-atrial (LA) action potentials were recorded with standard microelectrodes and ionic currents with whole-cell patch clamp before and after ade...

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ژورنال

عنوان ژورنال: Circulation

سال: 2002

ISSN: 0009-7322,1524-4539

DOI: 10.1161/01.cir.0000016062.80020.11